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Título : Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection
Autor : González Díaz, Sandra Milena
Taborda Vanegas, Natalia Andrea
Rugeles López, María Teresa
Palabras clave : Antiviral immune response
HIV infection
Resistance to HIV
HIV control
CD8+ T cells
Human immunodeficiency viruses
Fecha de publicación : 2017
Editorial : Frontiers Research Foundation
Citación : Gonzalez SM, Taborda NA, Rugeles MT. Role of Different Subpopulations of CD8(+) T Cells during HIV Exposure and Infection. Front Immunol. 2017 Aug 7;8:936. DOI: 10.3389/fimmu
Abstract : During HIV infection, specific responses exhibited by CD8+ T cells are crucial to establish an early, effective, and sustained viral control, preventing severe immune alterations and organ dysfunction. Several CD8+ T cells subsets have been identified, exhibiting differences in terms of activation, functional profile, and ability to limit HIV replication. Some of the most important CD8+ T cells subsets associated with viral control, production of potent antiviral molecules, and strong polyfunctional responses include Th1-like cytokine pattern and Tc17 cells. In addition, the expression of specific activation markers has been also associated with a more effective response of CD8+ T cells, as evidenced in HLA-DR+ CD38- cells. CD8+ T cells in both, peripheral blood and gut mucosa, are particularly important in individuals with a resistant phenotype, including HIV-exposed seronegative individuals (HESNs), long-term non-progressors (LTNPs) and HIV-controllers. Although the role of CD8+ T cells has been extensively explored in the context of an established HIV-1 infection, the presence of HIV-specific cells with effector abilities and a defined functional profile in HESNs, remain poorly understood. Here, we reviewed studies carried out on different subpopulations of CD8+ T cells in relation with natural resistance to HIV infection and progression. Keywords: CD8+ T cells subpopulations, HIV infection, Natural resistance to HIV, spontaneous control of HIV replication, antiviral immune response
Grupo de INV. : Inmunovirología
URI : http://hdl.handle.net/10495/11509
ISSN : 16643224
Aparece en las colecciones: Instituto de Investigaciones Médicas

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