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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/11655
Título : Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study
Autor : Muñoz Contreras, Angélica María
Velásquez Rodríguez, Claudia María
Agudelo Ochoa, Gloria María
Uscátegui Peñuela, Rosa Magdalena
Estrada Restrepo, Alejandro
Patiño Villada, Fredy Alonso
Parra Sosa, Beatriz Elena
Parra, María Victoria
Bedoya Berrío, Gabriel de Jesús
Palabras clave : Body mass index
Adiposity
Polymorphisms
Environmental factors
Youth
Fecha de publicación : 2017
Editorial : Springer Nature
Citación : Muñoz A, Velásquez C, Agudelo G, Uscátegui R, Estrada A, Patiño F, Parra B, Parra M, Bedoya G. Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study. Genes & Nutrition. 2017: 12:19. DOI: 10.1186/s12263-017-0567-1
Abstract : Background: A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate the effect of perinatal and socioeconomic factors on these associations. Methods: The anthropometry, socioeconomic and perinatal conditions and 10 polymorphisms were evaluated in 1081 young people between 10 and 18 years old. Genotypic associations were calculated using logistic and linear models adjusted by age, gender, and pubertal maturation, and a genetic risk score (GRS) was calculated by summing the number of effect alleles. Results: We found that AGT-rs699 and the IRS2-rs1805097 variants were significantly associated with excess weight, OR = 1.25 (CI 95% 1.01–1.54; p = 0.034); OR = 0.77 (CI 95% 0.62–0.96; p = 0.022), respectively. AGT-rs699 and FTO-rs17817449 variants were significantly and directly associated with body mass index (BMI) (p = 0.036 and p = 0.031), while IRS2-rs1805097 and UCP3-rs1800849 were significantly and negatively associated with BMI and waist circumference, correspondingly. Each additional effect allele in GRS was associated with an increase of 0.020 log(BMI) (p = 0.004). No effects from the socioeconomic and perinatal factors evaluated on the association of the candidate genes with the phenotypes were detected. Conclusions: Our observation suggests that AGT-rs699 and FTO-rs17817449 variants may contribute to the risk development of excess weight and an increase in the BMI, while IRS2-rs1805097 showed a protector effect; in addition, UCP3- rs1800849 showed a decreasing waist circumference. Socioeconomic and perinatal factors had no effect on the associations of the candidate gene.
Grupo de INV. : Alimentación y Nutrición Humana
Ciencias Aplicadas a la Actividad Física y el Deporte GRICAFDE
Demografía y Salud
Genética Molecular (GENMOL)
URI : http://hdl.handle.net/10495/11655
ISSN : 18653499
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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