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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/11712
Título : Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial
Autor : Agudelo Ochoa, Gloria María
Pulgarín Zapata, Isabel Cristina
Velásquez Rodríguez, Claudia María
Duque Ramírez, Mauricio
Naranjo Cano, Mauricio
Quintero Ortiz, Mónica M.
Lara Guzmán, Oscar Javier
Muñoz Durango, Katalina
Palabras clave : Cardiovascular disease
Chlorogenic acids
Phenolic acids
Oxidative stress
Diterpenes
Caffeine
Flow-mediated dilation
Cholesterol
Fecha de publicación : 2016
Editorial : Oxford University Press
Citación : Agudelo-Ochoa GM, Pulgarín-Zapata IC, Velásquez-Rodriguez CM, Duque-Ramírez M, Naranjo-Cano M, et al. Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial. Journal Nutr, 2016; 146(3): 524-31.
Abstract : Background: Coffee, a source of antioxidants, has controversial effects on cardiovascular health. Objective: We evaluated the bioavailability of chlorogenic acids (CGAs) in 2 coffees and the effects of their consumption on the plasma antioxidant capacity (AC), the serum lipid profile, and the vascular function in healthy adults. Methods: Thirty-eight men and 37 women with a mean 6 SD age of 38.5 6 9 y and body mass index of 24.1 6 2.6 kg/m2 were randomly assigned to 3 groups: a control group that did not consume coffee or a placebo and 2 groups that consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or high (HCCGA; 780 mg) CGA content. Both were low in diterpenes (0.83 mg/d) and caffeine (193 mg/d). Plasma caffeic and ferulic acid concentrations were measured by GC, and the plasma AC was evaluated with use of the ferric-reducing antioxidant power method. The serum lipid profile, nitric oxide (NO) plasma metabolites, vascular endothelial function (flow-mediated dilation; FMD), and blood pressure (BP) were evaluated.Results: After coffee consumption (1 h and 8 wk), caffeic and ferulic acid concentrations increased in the coffee-drinking groups, although the values of the 2 groups were significantly different (P < 0.001); caffeic and ferulic acid concentrations were undetectable in the control group. At 1 h after consumption, the plasma AC in the control group was significantly lower than the baseline value (22%) and significantly increased in the MCCGA (6%) and HCCGA (5%) groups (P < 0.05). After 8 wk, no significant differences in the lipid, FMD, BP, or NO plasma metabolite values were observed between the groups. Conclusions: Both coffees, which contained CGAs and were low in diterpenes and caffeine, provided bioavailable CGAs and had a positive acute effect on the plasma AC in healthy adults and no effect on blood lipids or vascular function. The group that did not drink coffee showed no improvement in serum lipid profile, FMD, BP, or NO plasma metabolites. This trial was registered at registroclinico.sld.cu as RPCEC00000168.
Grupo de INV. : Alimentación y Nutrición Humana
URI : http://hdl.handle.net/10495/11712
ISSN : 15416100
00223166 E
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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