Escudo Universidad de Antioquia

Sistema de Bibliotecas

Universidad de Antioquia

Biblioteca Digital


Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/11715
Título : Cardio-metabolic parameters are associated with genetic admixture estimates in a pediatric population from Colombia
Autor : Muñoz Contreras, Angélica María
Velásquez Rodríguez, Claudia María
Bedoya Berrío, Gabriel de Jesús
Palabras clave : Ancestry
Admixed population
Cardio-metabolic parameters
Youth
Fecha de publicación : 2016
Editorial : Springer Nature
Citación : Muñoz AM, Velásquez CM, Bedoya G. Cardio-metabolic parameters are associated with genetic admixture estimates in a pediatric population from Colombia. BMC genetics, 2016; 17(1): 93. DOI: 10.1186/s12863-016-0402-5
Abstract : Background: There are different genetic patterns for cardio-metabolic parameters among different populations. Additionally, it has been found that ancestral genetic components (the proportion of Amerindian, European and African) in admixed Latin American populations influence an individual’s susceptibility to cardio-metabolic disorders. The aim of this study was to evaluate the effect of ancestral genetic composition on a series of cardio-metabolic risk factors in a young admixed population from Colombia. Results: In a sample of 853 Colombian youth, 10 to 18 years old, the mean European contribution was 66.6 % (range: 41–82 %), the mean African contribution was 14 % (range: 4–48 %), and the mean Amerindian contribution was 19.4 % (range: 10–35 %) using a panel of 40 autosomal ancestry-informative markers (AIMs). We assessed the degree of association between ancestral African, Amerindian and European genetic components and measures of body mass index, waist circumference, fasting glucose, fasting insulin, insulin resistance, triglycerides, high-density lipoprotein, and systolic and diastolic blood pressure. Two of the nine measures assessed presented a nominal significant association with ancestral components after adjusting for confounding variables: triglyceride levels were associated with the Amerindian component (OR = 1.06, 98.3 % CI = 1.01–1.11, P = 0.002) and systolic blood pressure was associated with the European component (OR = 0.93, 98.3 % CI = 0.87 to 0.99, P = 0.008) and the African component (OR = 1.07, CI = 1.01–1.14 P = 0.008), although it was not significant following a global Bonferroni correction. Additionally, insulin levels and insulin resistance showed associations with the African component. Conclusions: Our findings support the idea that an Amerindian ancestral component may act as a risk factor for high triglyceride levels. In addition, an African ancestral component confers a risk for high systolic blood pressure, and a European ancestry serves as a protective factor for this condition in a young admixed population from Colombia. However, these results should be confirmed in a larger population.
Grupo de INV. : Alimentación y Nutrición Humana
URI : http://hdl.handle.net/10495/11715
ISSN : 14712156
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
MunozAngelica_2016_CardioMetabolicParametersAssociated.pdfArtículo de revista 574,71 kBAdobe PDFVisualizar/Abrir


Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 


Unidad de Gestión Tecnológica /Sistema de Bibliotecas / Universidad de Antioquia / Cl. 67 Nº 53 - 108 - Bloque 8 Conmutador: 219 51 51- 219 51 40 comunicacionessistemadebibliotecas@udea.edu.co Medellín - Colombia