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Título : Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach
Autor : Quintero Velez, Juan Carlos
Paternina Tuirán, Luis Enrique
Uribe Yepes, Alexander Dario
Muskus Lopez, Carlos Enrique
Hidalgo, Marylin
Gil Mora, Juliana
Cienfuegos Gallet, Astrid Vanessa
Osorio Quintero, Lisardo
Rojas Arbelaez, Carlos Alberto
Palabras clave : Eco-epidemiological
Epidemiologic Studies
Rickettsial
Rickettsia Infections
Seropositivity
Eco-epidemiológico
Estudios Epidemiológicos
Infecciones por Rickettsia
Fecha de publicación : 2017
Editorial : Public Library of Science
Citación : Quintero V JC, Paternina T LE, Uribe Y A, Muskus C, Hidalgo M, Gil J, Cienfuegos G AV, Osorio Q L, Rojas A C. Eco-epidemiological analysis of rickettsial seropositivity in rural areas of Colombia: A multilevel approach. PLoS Negl Trop Dis. 2017 Sep 18;11(9):e0005892
Abstract : Rickettsiosis is a re-emergent infectious disease without epidemiological surveillance in Colombia. This disease is generally undiagnosed and several deadly outbreaks have been reported in the country in the last decade. The aim of this study is to analyze the eco-epidemiological aspects of rickettsial seropositivity in rural areas of Colombia where outbreaks of the disease were previously reported. A cross-sectional study, which included 597 people living in 246 households from nine hamlets in two municipalities of Colombia, was conducted from November 2015 to January 2016. The survey was conducted to collect sociodemographic and household characteristics (exposure) data. Blood samples were collected to determine the rickettsial seropositivity in humans, horses and dogs (IFA, cut-off = 1/128). In addition, infections by rickettsiae were detected in ticks from humans and animals by real-time PCR targeting gltA and ompA genes. Data was analyzed by weighted multilevel clog-log regression model using three levels (person, household and hamlets) and rickettsial seropositivity in humans was the main outcome. Overall prevalence of rickettsial seropositivity in humans was 25.62% (95%CI 22.11-29.12). Age in years (PR = 1.01 95%CI 1.01-1.02) and male sex (PR = 1.65 95%CI 1.43-1.90) were risk markers for rickettsial seropositivity. Working outdoors (PR = 1.20 95%CI 1.02-1.41), deforestation and forest fragmentation for agriculture use (PR = 1.75 95%CI 1.51-2.02), opossum in peridomiciliary area (PR = 1.56 95%CI 1.37-1.79) and a high proportion of seropositive domestic animals in the home (PR20-40% vs <20% = 2.28 95%CI 1.59-3.23 and PR>40% vs <20% = 3.14 95%CI 2.43-4.04) were associated with rickettsial seropositivity in humans. This study showed the presence of Rickettsia antibodies in human populations and domestic animals. In addition, different species of rickettsiae were detected in ticks collected from humans and animals. Our results highlighted the role of domestic animals as sentinels of rickettsial infection to identify areas at risk of transmission, and the importance of preventive measures aimed at curtailing deforestation and the fragmentation of forests as a way of reducing the risk of transmission of emergent and re-emergent pathogens.
Grupo de INV. : CENTAURO
Epidemiología
Grupo de Investigación en Microbiología Básica y Aplicada-Microba
Programa de Estudio y Control de Enfermedades Tropicales (PECET)
Salud y Ambiente
URI : http://hdl.handle.net/10495/11859
ISSN : 19352727
19352735 E
Aparece en las colecciones: Instituto de Investigaciones Médicas

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